Web18 Oct 2024 · The thiazide class diuretics are first-line agents for managing hypertension either as monotherapy or as a fixed-dose combination with other antihypertensive drugs. … Web23 Jan 2024 · National Center for Biotechnology Information

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Web18 Oct 2015 · Although thiazide diuretics reduce blood pressure as effectively as other drugs, 1 one of the recognised disadvantages of drugs of this class is that they adversely affect lipid and glucose metabolism. 2 They cause a slight increase in serum LDL cholesterol and triglycerides, a decrease in serum HDL cholesterol, and an increase in … WebAn oral dose of hydrochlorothiazide is 65-75% bioavailable, with a T max of 1-5 hours, and a C max of 70-490ng/mL following doses of 12.5-100mg. 10, 11 When taken with a meal, … sims 3 teen male clothes

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Thiazide diuretics are primarily used to treat the hypertension (high blood pressure) and edema (swelling) caused by water overload as well as certain conditions related to unbalanced calcium metabolism. Water balance Hypertension There are many causes of hypertension (high blood pressure), including … See more Thiazide refers to both a class of sulfur-containing organic molecules and a class of diuretics based on the chemical structure of benzothiadiazine. The thiazide drug class was discovered and developed at See more Thiazide diuretics control hypertension in part by inhibiting reabsorption of sodium (Na ) and chloride (Cl ) ions from the distal convoluted tubules in the kidneys by blocking the thiazide-sensitive Na -Cl symporter. The term "thiazide" is also often used for drugs … See more The thiazide diuretics were developed by scientists Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of See more Contraindications include: • Hypotension • Allergy to sulphur-containing medications See more • Hypokalemia – Thiazide diuretics reduce potassium concentration in blood through two indirect mechanisms: inhibition of sodium-chloride symporter at distal convoluted tubule See more Thiazides pass into breast milk and can decrease the flow of breast milk. Thiazides have been associated with significant side effects in some nursing infants and should be administered to nursing mothers with caution. See more Web9 Jul 2014 · Only thiazide diuretics and the majority of thiazide-like diuretics are used essentially unchanged and they are known not to undergo metabolism. As was expected due to the structural similarity, the antihypertensive drugs belonging to the same drug category and presenting structural similarity are metabolized in the same pattern. WebFinally, thiazides can tamper with the metabolism of glucose and fat, which may lead to hyperglycemia, hyperlipidemia, and an increase in serum cholesterol and LDL. As far as … rbc investor services online