Smarce1是什么
WebApr 23, 2024 · Moreover, SMARCE1 was an independent risk factor of poor prognosis ( P <0.01). Functional study revealed that overexpression of SMARCE1 markedly promoted the proliferation, migration, and invasion of GC cells in vitro and tumorigenesis in vivo. Furthermore, SMARCE1 activated the MAPK/ERK signaling pathway. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.
Smarce1是什么
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WebTargeted DNA sequencing revealed SMARCE1 mutations in 33/34 analyzed samples, accompanied by a nuclear loss of expression determined via immunohistochemistry and a decreased SMARCE1 transcript expression in the tumor cells. Analysis of time to progression or recurrence of patients within the clear cell meningioma group (n = 14) in … WebJun 9, 2024 · SMARCE1-deficient cells, which are a model for clear cell meningioma, are sensitive to ncBAF complex inhibition.
WebAug 5, 2016 · SMARCE1 knockdown reduces lung metastasis of breast cancer in vivo. a Expression levels of SMARCE1 mRNA and protein in LM-EV and LM-SMARCE1-KD cells.b Effect of SMARCE1 knockdown on the growth of xenografts in the fourth inguinal mammary fat pads of female NSG mice.c Spontaneous lung metastasis from orthotopic sites. … WebFeb 5, 2024 · SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. Gene ID: 6605, updated on 5-Feb-2024. Gene type: …
WebSMARCE1 drives invasion by serving as a master regulator of genes encoding proinvasive ECM and proteases required to degrade basement membrane. In functional studies in 3D cultures and animal models, SMARCE1 is dispensable for tumor growth but is required for the invasive and metastatic progression of cancers. WebSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. Gene namei. Official gene symbol, which is typically a short form of the gene …
WebThe SMARCE1 gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate …
WebPrestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution. Synonym (s): Anti-BRG1-associated factor 57, Anti-SWI/SNF … hawaiian tropic dry oilWebFeb 3, 2013 · William Newman, Gareth Evans and colleagues report that loss-of-function mutations in SMARCE1 cause an inherited disorder characterized by multiple spinal meningiomas. Tumors from individuals with ... bosch thermador dishwasher shu66c06uc/14WebSep 29, 2024 · N6-methyladenosine (m6A) is the most abundant mRNA internal modification and has reportedly been linked to aerobic glycolysis, a hallmark event in tumor development. This work focuses on the role of the m6A methyltransferase WT1-associated protein (WTAP) in metabolic reprogramming and development of colon adenocarcinoma (COAD) … bosch thermador partsWebNov 1, 2024 · A United Kingdom case series has described familial CCM with germline SMARCE1 mutation in 14% cases of solitary meningioma. They have identified cases of multiple spinal CCM, with the presence of somatic SMARCE1 mutation, as well as germline SMARCE1 mutation in 4 of the 9 families studied . The UK group also reported a case of … hawaiian tropic expiration dateWebSMARCE1 mutation screening in classification of clear cell meningiomas. These results expand the spectrum of pathogenic variants in SMARCE1 and show that mutation … bosch thermador gaggaenWebKnockdown of Smarcc1 or Smarce1 suppressed loss of Nanog expression in multiple forms of differentiation. This effect occurred in the absence of self-renewal factors normally required for Nanog expression (e.g., Oct4), possibly indicating that changes in chromatin structure, rather than loss of self-renewal gene transcription per se, trigger ... bosch thermador spiffsWebMay 18, 2024 · Here, we report on the function of Smarce1, a component of the SWI/SNF complex, through the phenotypic analysis of homozygous mutant embryonic stem (ES) … bosch thermador refrigerator