Pten nuclear functions

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August undefined, 2024

WebApr 15, 2015 · The N-terminal region of PTEN is important for the control of PTEN … WebApr 4, 2012 · Growing evidence demonstrates important functions of nuclear PTEN in …

The Role of PTEN in β-Cell Growth - PMC - National Center for ...

WebJan 12, 2007 · The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as a plasma-membrane lipid-phosphatase antagonizing the phosphoinositide 3-kinase/AKT cell survival pathway. However, PTEN is also found in cell … WebApr 15, 2011 · It has also become increasingly evident that PTEN functions in the nucleus and may play an important part in transcription regulation, but its nuclear targets remain elusive. In this report, we demonstrate the transcription factor cyclic AMP response element-binding protein (CREB) is a protein target of PTEN phosphatase and that PTEN deficiency ... copper canyon golf utah

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WebDespite the early recognition of nuclear PTEN, the understanding of the mechanisms of its nuclear localization, function in the nucleus, and importance in biology and human disease has been lacking. Over the last decade, emerging concepts for the complex involvement of nuclear PTEN in a variety of processes, including genome maintenance and DNA ... WebOver the last several years, PTEN nuclear functions have emerged as important … WebNov 16, 2024 · While PTEN can be targeted by HECT-type E3 ubiquitin ligases for nuclear import and proteasomal degradation, studies have shown that several deubiquitinating enzymes, including HAUSP/USP7, USP10 ... famous gothic cathedral in paris

PTEN, more than the AKT pathway Carcinogenesis Oxford …

PTEN gene: MedlinePlus Genetics

WebOct 15, 2012 · Whether this function requires the lipid phosphatase activity of PTEN is under debate. More recently, nuclear PTEN has been found to interact with the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase that promotes cell cycle progression by degrading components of the cell cycle machinery. WebPhosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a major nonredundant, dose-dependent tumor-suppressor gene able to act in both a phosphatidylinositol 3-kinase (PI3K)-dependent and -independent manner [].PTEN protein is involved in the regulation of several crucial cell functions, such as maintenance of … copper canyon grill near meWebJul 27, 2015 · The function of PTEN does not rely solely on its lipid phosphatase activity. PI(3,4,5)P 3 was shown to localize also in the nucleus and although its levels were affected by PI3K inhibitors, they remained unaffected after the expression of PTEN implying that nuclear PTEN serves another function in the cell . Indeed, localization of PTEN in the ... famous gothic cathedrals in france map

"WebNov 11, 2024 · It is believed that cytoplasmic PTEN exerts its lipid phosphatase activity, while nuclear PTEN performs various cellular functions largely through lipid-phosphatase-independent mechanisms 10,12 ... " - Pten nuclear functions

Pten nuclear functions

The nuclear affairs of PTEN Journal of Cell Science The Compan…

WebLoss of PTEN promotes cardiac regeneration and protects the heart from myocardial infarction. A, A schematic diagram of the research design and experimental procedures.Four-week-old Pten fl/fl; α-MHC-MerCreMer (Pten cKO) mice, and Pten fl/fl (control) mice were intraperitoneally injected with tamoxifen (75mg/kg body weight). Four … WebApr 14, 2024 · PTEN is a tumor suppressor with phosphatase activity that inhibits the development of many tumors . Li et al. found that OTUD5 stabilizes PTEN through deubiquitination and that the overexpression of OTUD5 inhibits NSCLC cell proliferation, invasion and migration (Figure 3E). In cervical cancer, OTUD5 also plays an important …

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WebAug 15, 2004 · Cellular PTEN function appears to be regulated by controlling both the … WebJan 30, 2024 · Originally discovered and characterized as a negative regulator of the …

WebJun 29, 2024 · Nuclear PTEN plays an important role during mitosis. To understand the molecular basis by which PTEN mediates mitotic progression, we examined whether PTEN regulated the formation of mitotic checkpoint complex (MCC). We observed that arsenic trioxide, a mitotic inducer, stimulated nuclear translocation of PTEN in a time-dependent … WebApr 13, 2011 · Emerging evidence demonstrates that PTEN has various nuclear functions in addition to its established roles in the cytoplasm ().In addition to controlling chromosome stability and DNA repair (), nuclear PTEN is also involved in transcriptional regulation by targeting a variety of transcription factors ().The phosphorylation-dependent transcription …

WebJun 1, 2024 · PTEN lacks a canonical nuclear localization signal or nuclear export … WebJan 12, 2007 · Regulation of the PTEN tumor suppressor protein is poorly understood. In this issue, Wang et al. (2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability.

WebWe show that PTEN status serves as both a novel biomarker for MLN4924 response in GBM and reveals a vulnerability to TOP2A inhibitors in combination with MLN4924. ... Loss of PTEN and its nuclear functions is associated with resistance to MLN4924. Time-course proteomics identified elevated TOP2A in resistant models through treatment.

WebMar 28, 2024 · Osteoclasts (OCs), which are responsible for bone resorption, play a critical role in cholesterol-induced bone loss and recent studies have suggested that various micro-RNAs (miRs) contribute to modulating OCs. We hypothesized that 7-ketocholesterol (7-KC), a metabolite responsible for cholesterol-induced bone loss, induces miR-107-5p, which … famous gothic literature quotesWebMay 1, 2024 · Search life-sciences literature (41,809,309 articles, preprints and more) (41,809,309 articles, preprints and more) famous gothic booksWebOct 1, 2024 · Members of the HECT family of E3 ubiquitin ligases have emerged as prominent regulators of PTEN function, subcellular localization and levels. ... Monoubiquitination of PTEN at Lys13 and Lys289 by NEDD4 was also shown to lead to PTEN nuclear import, which is a prerequisite for nuclear PTEN to fully exert its tumor … copper canyon grill woodmore town centerWebTo function, the PTEN enzyme attaches (binds) to another PTEN enzyme (dimerizes) then … copper canyon harley butte montanaWebNuclear PTEN plays an important role in tumor suppressing, and the absence of nuclear PTEN is associated with increased aggressiveness in cancers (Gimm et al. 2000; Baker 2007). Therefore, it is of great importance that we summarize the latest research progress on functions of nuclear PTEN, especially the interplay with histones on chromatin ... famous gothic poetsWebMay 1, 2024 · Search life-sciences literature (41,104,240 articles, preprints and more) (41,104,240 articles, preprints and more) famous gothic novel titlesWebDec 16, 2009 · Based on the observation that PTEN functions in both nucleus and cytoplasm, two studies have examined nuclear and cytoplasmic PTEN expression separately [23, 34]. Results were concordant, each study showing that nuclear staining was reduced more frequently than cytoplasmic staining [23, 34]. Reduced PTEN expression was … famous gothic paintings