Lc3-interacting region lir

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August undefined, 2024

Web30 jun. 2024 · Bioinformatics data-mining revealed that β-gB1 contains the canonical LIR (LC3 interacting region) motif. Functionally, we showed that the β-ginkgotide β-gB1 displays cytoprotective and adaptogenic properties to modulate cellular homeostasis and survivability against hypoxia-induced stress. Web15 feb. 2024 · ATG8 proteins have a pocket on their surface called the LC3-interacting region (LIR)–docking site (LDS), ... These adapters may also be degraded. Finally, a third class of LIR motif–containing proteins bind LC3 but escape degradation because, for example, the LC3 they bind falls off the surface before fusion with the lysosome ...

SARS-CoV-2 promote autophagy to suppress type I interferon

Web10 jun. 2024 · LIR-mediated interaction with ATG8 proteins. The complex between LC3B and p62 [PDB entry: 2ZJD ( Ichimura et al., 2008 )] is reported as an example. LC3B mediates protein-protein interactions and recruits the autophagy receptors through the binding of a short linear motif, called LIR. Web28 dec. 2024 · Binding ER-phagy receptors with LC3 occurs via an LC3-interacting region (LIR) motif [72,73]. In some cases, these receptors bind through the FIP200 protein found in the ULK complexes . ER stress activates autophagy by upregulating transcription of autophagy machinery components and modulating microtubule-associated LC3 protein. tax related terms

NudCL2 is an autophagy receptor that mediates selective …

Web4 mei 2024 · Atg8 proteins are attached to membrane in a conjugation reaction and the cargo receptors bind them via short peptide motifs called Atg8-interacting motifs/LC3 … Web31 mrt. 2024 · LC3 interacting regions (LIRs), being quintessential for orchestrating diverse stages of autophagy, are a prominent example of SLiMs and mediate … WebThe four amino acid linear LC3 interaction region (LIR) is shown in bold in its broader amino acid context. (B) Surface representation of the LIR binding site of LC3B in complex with … tax related issues

Frontiers Disrupting the LC3 Interaction Region (LIR) Binding of ...

The LC3-conjugation machinery specifies cargo loading and …

Web3 jan. 2024 · The interaction is mediated by 15- to 20-amino-acid-long sequence motifs called LC3-interacting region (LIR) motifs that bind to the LIR docking site (LDS) of … WebShort linear motifs, known as LC3-interacting regions (LIRs), interact with mactoautophagy/autophagy modifiers (Atg8/LC3/GABARAP proteins) via a conserved … tax related news articlesWeb张慧芳，黄自能，陈蔚，孙林，刘伏友，肖力. 1中南大学湘雅二医院肾内科，长沙 410000. 自噬是消除聚集的蛋白质及受损细胞器的过程，对于缓解应激、维持细胞稳态及细胞分化等至关重要[1-2]。 tax related jobs

"Web23 nov. 2024 · We found that Trim5α binds all mammalian ATG8s and that, unlike the typical LC3-interacting region (LIR) that binds to mammalian ATG8s through a β … " - Lc3-interacting region lir

Lc3-interacting region lir

iLIR@viral: A web resource for LIR motif-containing proteins

Web24 jun. 2024 · These receptors then bind to autophagosome membrane attached LC3 through their LC3-interacting regions (LIRs) to engage the autophagic machinery. ... Rendering the receptor inactive to function in selective autophagy even though its ability to interact with LC3 through the LIR was unaltered . Web5 jan. 2024 · To predict LC3-interacting region (LIR) motif among these DEGs, the iLIR database was selected to assess specific short linear sequences. To obtain potential upstream miRNA targets of these DEGs, the mRNA-miRNA interaction networks were predicted by miRWalk database.

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Web8 apr. 2024 · Efficient localization of HyD-2xLIRs-GFP to mRFP-LC3/GABARAP-positive autophagosomes. a Schematic model depicting the development of new autophagosome sensors. LIR: LC3-interacting region, HyD: hydrophobic domain. b Confocal images showing the cellular localization of HyD-LIR(X)-GFP or HyD-2xLIR(X)-GFP together with … Web3 mei 2024 · Nature Communications - Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP …

Web6 mei 2013 · We demonstrate that each of the human LC3 isoforms (LC3A, LC3B, and LC3C) interacts with Atg13 via the LC3 interacting region (LIR) of Atg13. Using X-ray … Web8 mei 2024 · This collective data show that M is a binding partner of LC3. Usually, binding partners of LC3 family members typically contain an LC3-interacting region (LIR). 2 LIRs form intermolecular β...

Web10 mrt. 2024 · Using analytical gel filtration chromatography-based analyses, we further narrowed down the FIP200-binding region of Optineurin(33–209) to its LIR region, as the phosphomimetic S177E mutant of ... Web13 mei 2024 · LC3-II is the lipidated, phosphatidylethanolamine (PE)-conjugated membrane-associated species of LC3, which undergoes cleavage and lipidation following autophagy induction. The authors found that LC3-II is associated with immunopurified EVs [ 14 ], and is located within the lumen of purified EVs as evidenced by a protease-protection assay.

Web2 dagen geleden · TBC1D15 localized to damaged lysosomes via its C-terminal LC3-interacting region (LIR) motif, and its N terminus served as a platform to assemble the ALR machinery.

Web16 mrt. 2012 · TP53INP1-LC3 interaction occurs via a functional LC3-interacting region (LIR). Inactivating mutations of this sequence abolish TP53INP1-LC3 interaction, … tax relief 2021 covid tax-related transactionsWeb26 aug. 2024 · All of these receptors have an LC3-interacting region (LIR) motif to facilitate targeting to the autophagosomal membrane. Of the various cargo targeted by autophagy, intracellular bacterial pathogens represent one type of substrate that autophagy targets for degradation [9], [10], [11], [12]. tax related services fremont caWebpCMV-mCherry-p62是碧云天研发的在哺乳动物细胞中表达红色mCherry标签的人源p62融合蛋白的质粒。该质粒含有CMV启动子，为卡那霉素抗性，转染后能够在靶细胞中高效表达带有红色荧光蛋白mCherry标签的p62融合蛋白，呈现明亮的红色荧光，可以用于细胞自噬(autophagy)的研究 tax release formWeb12 mrt. 2024 · A variety of molecules involved in the autophagic pathway engage in specific interactions with a unique sequence motif referred to as the LIR (LC3-interacting region) motif. Although identification of conserved structural features of LIR motifs in complex with LC3-family members has established a canonical LIR motif, atypical conformations of … tax release scheduleWeb2 jun. 2024 · In this study, we identify NIMA-related kinase 9 (NEK9) as a GABARAPs-interacting protein and find that NEK9 and its LC3-interacting region (LIR) are required for primary cilia formation.... tax release datesWeb1 aug. 2013 · LIR-containing proteins include cargo receptors, members of the basal autophagy apparatus, proteins associated with vesicles and of their transport, Rab … tax related news