WebIFN-α2 has been used in the treatment of cancer such as bladder cancer, hepatocellular carcinoma, and leukemia. IFN-α2 augments the suppressed immune functions in patients with head and neck squamous cell carcinoma (HNSCC). IFN-α2 initiated T and NK cell mediated cytotoxicity of tumor cells through IFNγ dependent and independent mechanisms. There are 3 types of IFNs: Interferon type I, Interferon type II and Interferon type III. The type II IFN, also called IFNγ, is produced by specific cells of the immune system. Unlike type I and type III IFNs, IFNγ has only a modest role in directly restricting viral infections. Type I and type III IFNs act similarly. Meer weergeven Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Meer weergeven Human interferon alpha-2 (IFNα2) is a cytokine belonging to the family of type I IFNs. IFNα2 is a protein secreted by cells infected by a Meer weergeven When a cell is infected by a virus, some components of the virus, mainly viral nucleic acids, are recognized by specialized … Meer weergeven Induced IFNα2 is secreted by the infected cells and acts locally as well as systemically on cells expressing a specific cell surface receptor able to bind type I IFNs. The … Meer weergeven If given orally, IFNα2 is degraded by digestive enzymes and is no longer active. Thus, IFNα2 is mainly administrated by injection essentially subcutaneous or intramuscular. … Meer weergeven The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 and as all type I IFN genes, it is devoid of intron. The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 … Meer weergeven The broad spectrum of ISGs explains the wide range of biological activity of type I IFNs. In addition to their antiviral activity, type I IFNs also inhibit the proliferation of cells and regulate the activation of the immune system. Type I IFNs … Meer weergeven
Purified anti-human IFN-alpha2 Antibody, IFN-alpha2, M4509E12
WebIn general, IFN-beta had greater growth inhibitory and proapoptotic effects than IFN-alpha2 on all cell lines. The melanoma cell line WM9, sensitive to growth inhibition by IFNs, had … WebThe first clinical trials of the safety and efficacy of interferon-alpha2 (IFN-alpha2) were performed about 30 years ago. Since then, several single-arm studies have convincingly demonstrated that IFN-alpha2 is a highly potent anti-cancer agent in several cancer types but unfortunately not being explored sufficiently due to a high toxicity profile when using … caldwell brass catcher rail mount
Recombinant Mouse IFN-alpha 2/IFNA2 Protein, CF
Web15 sep. 2024 · Type I interferons (IFNA1, 147660; IFNB1, 147640; and IFNW1, 147553) bind to the type I IFN receptor (IFNAR) and elicit signaling events including activation of … WebInterferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface … WebView our 49 IFN-alpha products for your research including IFN-alpha Primary Antibodies, Proteins and Enzymes, ELISAs, Simple Plex Assays, Luminex ... Control for use with Human IFN-alpha and Human IFN-alpha 2/IFNA2 Simple Plex Cartridge Kitss . 899050. 1 Image. Ctrl. Show Size & Price. Recombinant Cotton Rat IFN-alpha (Cys109Tyr) Protein ... coachella fashion men 2017